The symptoms of the end stages of ALS vary for each case and depend largely on the specific neurons affected. The following is a review of what patients and their families can expect during the end stages of ALS. Most patients progress to the end stages of ALS within two to five years from diagnosis, and the disease is eventually terminal. It progresses relatively quickly, and there is no known cure. In the early stages, patients often experience muscle weakness, involuntary twitching, weakness of the limbs and slurred speech. Some cases are likely genetic, although the cause for most is hard to determine.
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